AJHSE is currently ACCEPTING manuscript submissions for Publication. Click on Submit                                                                                                                         AJHSE is currently ACCEPTING manuscript submissions for Publication. Click on Submit

EVALUATION OF ANTICONVULSANT ACTIVITY OF CALLISTEMON CITRINUS (CURTIS) SKEELS (MYRTACEAE) VOLATILE OIL

  • R. O. Imade Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria
  • A. M. Akhigbemen Department of Pharmacology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria
  • A. Uchendu Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria
  • C. L. Onyeagoro Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria
Keywords: Anticonvulsant, Callistemon citrinus, Pentylenetetrazol, Strychnine, Maximal electroshock

Abstract

The use of medicinal plants is on the rise due to the increase of various diseases and shortcomings of orthodox medicine. For many ailments including convulsion, conventional medicine has not been able to find a lasting solution. This study was directed towards assessing the ethnomedicinal use of Callistemon citrinus leaves in the management of convulsion. The volatile oil of the leaves was extracted and an acute toxicity test was carried out following Lorke’s description. Maximal electroshock (MES), strychnine and pentylenetetrazol anticonvulsant methods were used. Separate groups of albino mice were given 200, 400 and 800 mg/kg doses of the volatile oil. Drug solutions; 30 mg/kg phenobarbitone for MES and 2 mg/kg diazepam for strychnine and pentylenetetrazol models were administered as a positive control. The start of tonic leg extension, duration and percentage mortality was recorded. Doses of 200 and 400 mg/kg significantly (P<0.05) inhibited seizure in the mice with scores of 40 % each in the MES model. There was a dose-dependent reduction in the duration of seizures with 68.47, 70.27 and 81.08 % reductions in the pentylenetetrazol model. No significant coverage was given in the strychnine model. C. citrinus oil protected the mice against pentylenetetrazol and maximal electroshock-induced convulsion hence could contribute to the medical treatment of epilepsy.

Published
2021-11-01
How to Cite
Imade, R. O., Akhigbemen, A. M., Uchendu, A., & Onyeagoro, C. L. (2021). EVALUATION OF ANTICONVULSANT ACTIVITY OF CALLISTEMON CITRINUS (CURTIS) SKEELS (MYRTACEAE) VOLATILE OIL. African Journal of Health, Safety and Environment, 2(2), 117 - 125. https://doi.org/10.52417/ajhse.v2i2.165